Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor

Dennis J. Slamon

2006

Scholarcy highlights

  • The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor
  • This gene has been shown to be amplified in human breast cancer cell lines
  • HER-2/neu was found to be amplified from 2- to greater than 20-fold in 30% of the tumors
  • Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer
  • HER-2/neu amplification had greater prognostic value than most currently used prognostic factors, including hormonal-receptor status, in lymph node-positive disease. These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of human breast cancer
  • Please read our Terms of Service before submitting your own eLetter

Need more features? Save interactive summary cards to your Scholarcy Library.