Bone Resorption by Osteoclasts

Bone resorption is the unique function of the osteoclast, and anti-osteoporosis therapy to date has targeted this cell

S. L. Teitelbaum

2002

Scholarcy highlights

  • Bone resorption is the unique function of the osteoclast, and anti-osteoporosis therapy to date has targeted this cell
  • The osteoclast is a specialized macrophage polykaryon whose differentiation is principally regulated by macrophage colony-stimulating factor, RANK ligand, and osteoprotegerin
  • Reflecting integrin-mediated signals, the osteoclast develops a specialized cytoskeleton that permits it to establish an isolated microenvironment between itself and bone, wherein matrix degradation occurs by a process involving proton transport
  • Osteopetrotic mutants have provided a wealth of information about the genes that regulate the differentiation of osteoclasts and their capacity to resorb bone

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