The Bcl-2 Protein Family: Arbiters of Cell Survival

Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens

Jerry M. Adams; Suzanne Cory

2002

Scholarcy highlights

  • Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens
  • More distant relatives instead promote apoptosis, apparently through mechanisms that include displacing the adapters from the pro-survival proteins
  • Bcl-2 family members are essential for maintenance of major organ systems, and mutations affecting them are implicated in cancer
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