Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

There is growing evidence that T helper cell subsets can be differentially recruited to promote different types of inflammatory reactions

Federica Sallusto; Charles R. Mackay; Antonio Lanzavecchia

2002

Scholarcy highlights

  • There is growing evidence that T helper cell subsets can be differentially recruited to promote different types of inflammatory reactions
  • An antibody to CCR3 was used to isolate T cells from peripheral blood that give rise to TH2-polarized cell lines and to identify TH2 cells derived from na─▒ve T cells in vitro
  • The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils
  • The CCR3+ cells account for only a fraction of all CD69+ cells
  • The difficulty in obtaining pure CCR3+ T cell lines by direct sorting from peripheral blood may arise from the low level of CCR3 expression and the high contamination by negative cells
  • We analyzed T cells that infiltrate the skin of a patient with atopic eczema and eosinophilic infiltration and found that up to 20% of CD3+ T cells express CCR3
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