Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

NIH 3T3 fibroblasts stably transformed with a constitutively active isoform of p21Ras, H-RasV12, produced large amounts of the reactive oxygen species superoxide. ·O2− production was suppressed by the expression of dominant negative isoforms of Ras or Rac1, as well as by treatment with a farnesyltransferase inhibitor or with diphenylene iodonium, a flavoprotein inhibitor

Kaikobad Irani; Yong Xia; Jay L. Zweier; Steven J. Sollott; Channing J. Der; Eric R. Fearon; Maitrayee Sundaresan; Toren Finkel; Pascal J. Goldschmidt-Clermont

2002

Scholarcy highlights

  • NIH 3T3 fibroblasts stably transformed with a constitutively active isoform of p21Ras, H-RasV12, produced large amounts of the reactive oxygen species superoxide. ·O2− production was suppressed by the expression of dominant negative isoforms of Ras or Rac1, as well as by treatment with a farnesyltransferase inhibitor or with diphenylene iodonium, a flavoprotein inhibitor
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