Thymotaxin, a chemotactic protein, is identical to beta 2-microglobulin

Thymotaxin, an 11-kilodalton protein chemotactic for rat bone marrow hematopoietic precursors, was purified from media conditioned by a rat thymic epithelial cell line

C Dargemont

2006

Scholarcy highlights

  • Thymotaxin, an 11-kilodalton protein chemotactic for rat bone marrow hematopoietic precursors, was purified from media conditioned by a rat thymic epithelial cell line
  • Chemotactic activity was observed with rat plasma beta 2m, human beta 2m, and mouse recombinant beta 2m, further supporting the identity of thymotaxin with beta 2m
  • The only rat bone marrow cells that migrated toward beta 2m were Thy1+ immature lymphoid cells devoid of T cell, B cell, and myeloid cell differentiation markers
  • By C Dargemont, D Dunon, MA Deugnier, M Denoyelle, JM Girault, F Lederer, KH Le, F Godeau, JP Thiery, BA Imhof

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