Design, Activity, and 2.8 Å Crystal Structure of a C 2 Symmetric Inhibitor Complexed to HIV-1 Protease

The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion

John Erickson; David J. Neidhart; John VanDrie; Dale J. Kempf; Xiu Chun Wang; Daniel W. Norbeck; Jacob J. Plattner; Judith W. Rittenhouse; Mary Turon; Norman Wideburg; William E. Kohlbrenner; Robert Simmer; Rosalind Helfrich; Deborah A. Paul; Mark Knigge

2006

Scholarcy highlights

  • The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion
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