ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

These results suggest that AGO4 and long small interfering RNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation

Daniel Zilberman; Xiaofeng Cao; Steven E. Jacobsen

2003

Scholarcy highlights

  • Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena
  • In addition,ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs that correspond to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation
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