METABOLISM OF N-HYDROXYGUANIDINES (N-HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES

The biotransformation of N-hydroxydebrisoquine, a model substrate for N-hydroxyguanidines, was studied in vitro with cultured and characterized porcine and human hepatocytes

Anja Kristina Froehlich

2005

Scholarcy highlights

  • The biotransformation of N-hydroxydebrisoquine, a model substrate for N-hydroxyguanidines, was studied in vitro with cultured and characterized porcine and human hepatocytes
  • Two glucuronides of the parent compound N-hydroxydebrisoquine were analyzed. One of these phase 2 metabolites could be identified as an O-glucuronide of an N-hydroxyguanidine by comparing it to a synthesized authentic compound
  • The N-hydroxylation of the corresponding reduced compound, which was previously described with microsomes, could not be detected in hepatocytes
  • Publication date, and citation information can be found at http://dmd.aspetjournals.org
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