Alterations in cat skeletal neuromuscular junctions following prolonged inactivity.

In this and a previous paper, we have studied neuromuscular junctions on normal, denervated and inactive cat skeletal muscle fibres

L Eldridge

2014

Scholarcy highlights

  • In this and a previous paper, we have studied neuromuscular junctions on normal, denervated and inactive cat skeletal muscle fibres
  • The extrajunctional receptor density was higher than in normal muscles but lower than in muscles denervated for up to 10 months
  • Reports suggested that inactivity of innervated muscle resulted in a transient spread of acetylcholine sensitivity to extrajunctional regions
  • More recent studies have confirmed that the extrajunctional ACh receptor density does increase and that this increase may be maintained for up to 2 months
  • The present work was undertaken to examine the effects of prolonged inactivity on skeletal neuromuscular junctions
  • There was no significant correlation between the normalized muscle weight and the mean ChE-staining length for either normal or inactive muscles
  • Do changes occur in the innervation pattern of inactive muscle? Secondly, does prolonged inactivity in result a maintained increase in extrajunctional AChreceptor density? Thirdly, is there a correlation between various possible results of inactivity?
  • These results make it clear that the increase in extrajunctional ACh receptor density following muscle inactivity is not a transient phenomenon

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