Neonatal thyroid‐stimulating hormone and association with attention‐deficit/hyperactivity disorder

We identified children with attention-deficit/ hyperactivity disorder 15 through linkage with the Norwegian Patient

Gro D. Villanger; Eivind Ystrom; Stephanie M. Engel; Matthew P. Longnecker; Rolf Pettersen; Alexander D. Rowe; Ted Reichborn‐Kjennerud; Heidi Aase


Scholarcy highlights

  • Thyroid-stimulating hormone regulates production and release of thyroid hormones from the thyroid gland. It is released from the pituitary under control of the hypothalamus and by negative feedback from circulating T3 and T4.2 Measuring neonatal thyroid-stimulating hormone concentrations 48-72 hours after birth screens for congenital hypothyroidism, allowing early treatment to avoid serious impairment
  • Several studies indicate that especially maternal thyroid hypothyroidism and hyperthyroidism during pregnancy is linked to the aetiology of attention-deficit/ hyperactivity disorder or related behavioural or cognitive problems in the child46; few studies investigate this relationship in neonates
  • This study examines the association between newborn concentrations of thyroid-stimulating hormone within normal ranges and childhood attention-deficit/ hyperactivity disorder using a population-based birth cohort
  • We identified interaction by sex in the lowest quintile of TSH, such that higher odds of ADHD was limited to girls; girls odds ratios 3.10 and boys OR 1.16
  • We observed elevated odds ratios at low and high TSH quintiles relative to quintile three indicating a possible non-linear relationship. These results were only significant among children in the lowest quintile of TSH, where odds of ADHD was approximately 1.5-fold higher than for children in the middle quintile, adjusted OR 1.60
  • We found that odds of ADHD was elevated among newborns with low TSH levels and that this association was mainly found among girls
  • Because our findings are suggestive of increased risk at very

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