Effect of Andrographis paniculata leaves extract on neurobehavioral and biochemical indices in scopolamineā€induced amnesic rats

Findings from this study showed that aqueous extract of A. paniculata had a modulatory effect on scopolamine-induced cognitive impairment and could be used in the management of memory loss

Bukola Christiana Adedayo; Oluwapelumi S. Jesubowale; Adeniyi Abiodun Adebayo; Ganiyu Oboh

2020

Scholarcy highlights

  • Andrographis paniculata is a medicinal herb that is used to treat various disease conditions due to its pharmacological properties
  • This study sought to assess the effect of A. paniculata extract on neurobehavioral and some biochemical parameters in scopolamine-induced amnesic rats
  • Thirty-five male rats were divided into seven groups and treated with aqueous extract of A. paniculata and donepezil for 14 days before administration of scopolamine
  • Behavioral studies were carried out to evaluate cognitive dysfunction in scopolamine-induced rats. Biochemical assays such as cholinesterases, monoamine oxidase, and purinergic activities were determined
  • Results revealed the presence of orientin, quercetin, caffeic acid, apigenin, and gallic acid in A. paniculata
  • Findings from this study showed that aqueous extract of A. paniculata had a modulatory effect on scopolamine-induced cognitive impairment and could be used in the management of memory loss
  • In-depth studies should be carried out on the toxic effect of A. paniculata to ascertain a safe dose for treatment

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