Botulinum toxin A and upper limb functional skills in hemiparetic cerebral palsy: a randomized trial in children receiving intensive therapy

We evaluated the additional effect of botulinum toxin A injections in the upper limb in children with hemiparetic cerebral palsy receiving an intensive occupational and physical therapy programme on function and activities in a randomized trial

L A W M Speth

2010

Scholarcy highlights

  • The beneficial effect of botulinum toxin A injections on children with spastic lower limb muscles has been quite well established
  • Active dorsal flexion of the wrist and the Pediatric Evaluation of Disability Inventory self-care score were better in the control group
  • We evaluated the additional effect of BTX-A injections in the upper limb in children with hemiparetic cerebral palsy receiving an intensive occupational and physical therapy programme on function and activities in a randomized trial
  • As could be expected from earlier research, this study showed a beneficial effect of BTX-A injections on wrist flexor tone
  • Dorsal flexion of the active wrist seems to be positively influenced by BTX-A injections for at least 9 months, this effect did not reach statistical significance
  • The statistically significant negative effect of BTX-A treatment on supination that we found can be explained by the very low baseline scores of three patients in the control group

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