Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung

Peroxiredoxins have been implicated in regulating many cellular processes including cell proliferation, differentiation and apoptosis

Joo Hun PARK; Young Sun KIM; Hye Lim LEE; Jin Young SHIM; Keu Sung LEE; Yoon Jung OH; Seung Soo SHIN; Young Hwa CHOI; Kwang Joo PARK; Rae Woong PARK; Sung Chul HWANG

2006

Scholarcy highlights

  • Peroxiredoxins have been implicated in regulating many cellular processes including cell proliferation, differentiation and apoptosis
  • Patients diagnosed with lung cancer who underwent surgery at Ajou Medical Center were enrolled
  • Immunohistochemical staining showed that the isoforms of Prx I, II, III and V were predominantly expressed in bronchial and alveolar epithelium as well as in alveolar macrophages of the normal mouse lung
  • The isoforms I, III and thioredoxin were overexpressed in lung cancer tissues compared with normal lungs
  • There was an increased amount of oxidized form of Prx I and a putative truncated form of Prx III in lung cancer samples when analysed on two-dimensional electrophoresis
  • The upregulation of Prx I, Prx III and thioredoxin in lung cancer tissue may represent an attempt by tumour cells to adjust to the microenvironment in a manner that is advantageous to survival and proliferation

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