9p21 deletion in the diagnosis of malignant mesothelioma, using fluorescence in situ hybridization analysis

The purpose of this study is to evaluate the diagnostic utility of 9p21 homozygous deletion assessed by fluorescence in situ hybridization in mesothelial neoplasm and hyperplasia of Japanese patients using paraffin-embedded tissue

Maiko Takeda

2010

Scholarcy highlights

  • Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as one of the most common genetic alterations in malignant mesotheliomas
  • Previous studies showed that this alteration might be useful for differentiating benign from malignant mesothelial tumors in cytology and surgical specimens
  • The purpose of this study is to evaluate the diagnostic utility of 9p21 homozygous deletion assessed by fluorescence in situ hybridization in mesothelial neoplasm and hyperplasia of Japanese patients using paraffin-embedded tissue
  • P16 protein immunoexpression was explored as a potential diagnostic aid
  • FISH analysis demonstrated 9p21 deletion in 35 of 40 cases with MM
  • Our study suggests that 9p21 homozygous deletion assessed by FISH on paraffin-embedded tissue may be very useful for differentiating MM from reactive mesothelial proliferation
  • If the address matches an existing account you will receive an email with instructions to retrieve your username

Need more features? Save interactive summary cards to your Scholarcy Library.