Association of the CT gene (CA) polymorphism with BMD in osteoporotic mexican women

Calcitonin plays a role in the pathogenesis of osteoporosis and genetic variations in or adjacent to the CT gene may be associated with loss of bone mineral density

JJ MagaƱa

2006

Scholarcy highlights

  • Calcitonin plays a role in the pathogenesis of osteoporosis and genetic variations in or adjacent to the CT gene may be associated with loss of bone mineral density
  • The allele A and genotype AA frequencies were significantly higher in osteoporotic women than in non-osteoporotic women
  • Genotype AA was associated with the presence of osteoporosis
  • The loss of lumbar BMD and T scores were related to the presence of allele A: subjects with a single A allele displayed lower values for lumbar BMD and T score than those who do not present any A allele
  • Analysis of potential confounder demonstrated that aging has a significant effect on osteoporosis development
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