Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils

To investigate the mechanisms underlying venom immunotherupy we examined the changes of blood basophil responsivetiess during VIT

MAREK JUTEL; U. R. M√úLLER; M. ERICKER; S. RIHS; W. J. PICHLER; C. DAHINDEN

2006

Scholarcy highlights

  • Seven bee venom allergic patients with a history of severe systemic reactions after a bee sting were investigated
  • We demonstrated a decrease of total histamine in peripheral blood leucocytes just after venom immunotherupy
  • Histamine release in response to all the stimuli used is not affected by ultra-rush VIT, if expressed as per cent release of total histamine
  • We found a significant reduction of LTC4 formation after VIT in samples stimulated with specific allergen)
  • Blood basophils are a target for VIT, which induces impaired release of both preformed and newly generated mediators
  • We believe the basic mechanisms of rapid clinical tolerance induced by ultra-rush VIT remain to be investigated

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