The involvement of eosinophils in the patch test reaction to aeroallergens in atopic dermatitis: its relevance for the pathogenesis of atopic dermatitis

After patch testing Atopic dermatitis patients with aeroallergens, an eczematous reaction develops after 24 48 hr at the site of application

P. L. B. BRUIJNZEEL

2006

Scholarcy highlights

  • After patch testing Atopic dermatitis patients with aeroallergens, an eczematous reaction develops after 24 48 hr at the site of application
  • Forty-eight to seventy-two hours after patch testing the eczematous reaction decreases. This coincides with disappearance of eosinophils from both the dermis and the epidermis; a dendritic staining pattern can be observed in the epidermis with anti-eosinophil peroxidase
  • Recent in vitro investigations revealed that eosinophils from the circulation of AD patients react more powerfully in in vitro test systems such as chemi luminescence, chemotaxis and endolhelial adherence and transmigration. 11 is very likely that this activated state is caused by the influence of lymphocyte-derived cytokines like IL-3, IL-5 and GM-CSF, since activated lymphocytes in the circulation may release these cytokines
  • The subsequent activation of eosinophils within the tissue leading to mediator release and the function of these mediators need to be further elucidated
  • The close similarity between the cellular events after a patch test reaction to aeroallergens in AD patients and those present in lesional AD skin suggests that the patch test reaction may be a helpful in rim model to study the pathogenesis of AD
  • The prominent involvement of lymphocytes and eosinophils in this reaction suggests some similarity with late phase reactions observed in the skin after intracutaneous allergen challenge

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