Seizures in autoimmune encephalitis—A systematic review and quantitative synthesis

This study aimed to evaluate the proportion of patients with seizures and electroencephalography abnormalities in autoimmune encephalitis and its most common subtypes

Anusha K. Yeshokumar; Arielle Coughlin; Jarrett Fastman; Kendall Psaila; Michael Harmon; Taylor Randell; Emily M. Schorr; Helen Han; Hai Hoang; Celine Soudant; Nathalie Jette

2021

Scholarcy highlights

  • This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis standards and was registered with the International Prospective Register of Systematic Reviews
  • This study aimed to evaluate the proportion of patients with seizures and electroencephalography abnormalities in autoimmune encephalitis and its most common subtypes
  • Of 3722 antibody-positive AE patients, 2601 had clinical seizures during the course of their illness
  • For all AE patients and in the anti-NMDARE subpopulation, seizures were more common in younger patients
  • This systematic review provides an estimate of the proportion of AE patients with seizures, confirming the magnitude of seizure burden in this population
  • Any queries should be directed to the corresponding author for the article

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