The analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate in children - clinical tools or scientific toys?

We aimed to evaluate whether the analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate is helpful in diagnosing and monitoring respiratory diseases in children

E. van Mastrigt

2014

Scholarcy highlights

  • Current monitoring strategies for respiratory diseases are mainly based on clinical features, lung function and imaging
  • As airway inflammation is the hallmark of many respiratory diseases in childhood, noninvasive methods to assess the presence and severity of airway inflammation might be helpful in both diagnosing and monitoring paediatric respiratory diseases
  • We aimed to evaluate whether the analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate is helpful in diagnosing and monitoring respiratory diseases in children
  • An extensive literature search was conducted in Medline, Embase and PubMed on the analysis and applications of VOCs in EB and EBC in children
  • There is a lack of longitudinal studies and external validation to reveal whether EB and EBC analysis have added value in the diagnostic process and follow‐up of children with respiratory diseases
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