New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP 3 ‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75 NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles

While the original identification of the hair organ-specific local HPA-axis was shown earlier in female human hair follicles gained from routine face-lift surgery,20 the present study provides the first evidence for a functional HPA axis in HFs electively taken from the balding area of male human individuals with Androgenetic alopecia, a condition found in every second man in European countries.46

T.W. Fischer; A. Bergmann; N. Kruse; K. Kleszczynski; C. Skobowiat; A.T. Slominski; R. Paus

2020

Scholarcy highlights

  • Human hair is highly responsive to stress, and human scalp hair follicles contain a peripheral neuroendocrine equivalent of the systemic hypothalamic–pituitary–adrenal stress axis
  • The current study aimed to establish a corticotropin-releasing hormone-based hair stress model – for the first time in male ex vivo human HFs derived from Androgenetic alopecia patients and to investigate the effects of a possible counteracting substance, the well-known phosphodiesterase inhibitor caffeine
  • Extracted HFs were cultivated in a validated hair organ culture model as previously described
  • adrenocorticotropic hormone in the outer and inner root sheaths was significantly increased by CRH 10À7 mol LÀ1, by 59% compared to control, while co-cultivation with caffeine 0Á005% led to a significant ACTH decrease by 23% compared to ACTH in HFs incubated with CRH 10À7 mol LÀ1 alone
  • CRH 10À7 mol LÀ1 only slightly reduced tyrosine kinase receptor A compared to control, but caffeine 0Á001% significantly enhanced TrkA immunoreactivity by 20% compared to CRH-treated HFs
  • While the original identification of the hair organ-specific local HPA-axis was shown earlier in female human hair follicles gained from routine face-lift surgery, the present study provides the first evidence for a functional HPA axis in HFs electively taken from the balding area of male human individuals with AGA, a condition found in every second man in European countries
  • Fischer et al 97 and that caffeine may effectively counteract stress-induced hair damage and possibly prevent stress-induced hair loss

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