Detection of thesatAgene and transferability of virginiamycin resistance inEnterococcus faeciumfrom food-animals

The present study showed that virginiamycin-resistant E. faecium isolates from pigs and broilers contained the satA gene and another not yet identi¢ed gene(s), conferring resistance to virginiamycin and pristinamycin IIA

Anette Marie Hammerum; Lars Bog� Jensen; Frank M�ller Aarestrup

2006

Scholarcy highlights

  • Streptogramins are a group of cyclic peptides produced by Streptomyces spp. as a mixture of components classi¢ed into two groups: streptogramin A and streptogramin B
  • Resistance to the streptogramin A group was observed in a human E. faecium strain in 1984
  • In Denmark, streptogramins have never been approved for human therapy, but virginiamycin has been used for animals for decades, and occurrence of resistance to virginiamycin has frequently been observed among E. faecium isolates from Danish food-producing animals
  • The obtained sequences were identical to the published sequence of satA from E. faecium BM4145
  • The present study showed that virginiamycin-resistant E. faecium isolates from pigs and broilers contained the satA gene and another not yet identi¢ed gene(s), conferring resistance to virginiamycin and pristinamycin IIA

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