HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population

This study shows a significant association between human leukocyte antigen alleles and bone mass loss in the population studied

K. Douroudis

2007

Scholarcy highlights

  • It is well established that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk
  • In order to evaluate the contribution of human leukocyte antigen alleles in bone mass loss, polymorphisms in the HLA class I and class II antigens were studied in 126 postmenopausal women of Greek origin
  • This study shows a significant association between HLA alleles and bone mass loss in the population studied
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