Hemodynamic and Electrocardiographic Effects of Disopyramide in Patients with Ventricular Arrhythmia

Antiarrhythmic and hemodynamic effects of i.v. disopyramide phosphate have been studied in nine patients, several in various degrees of cardiac decompensation, with sinus rhythm and persistent ventricular ectopic beats

Johan Hulting; Gunnar Rosenhamer

2010

Scholarcy highlights

  • Antiarrhythmic and hemodynamic effects of i.v. disopyramide phosphate have been studied in nine patients, several in various degrees of cardiac decompensation, with sinus rhythm and persistent ventricular ectopic beats
  • For 30 min, only one patient showed VEBs, and in three patients no VEBs were seen for three hours
  • Changes in cardiac output and pulmonary artery and central aortic pressures were measured in eight patients
  • In predicting myocardial depressant effects of DE, the control values for diastolic PAP seemed to be superior to central venous pressure, cardiac index and systolic time intervals
  • Mean arterial pressure measured 5 and 10 min after drug administration showed no significant change, indicating that vasoconstrictor reflexes were well preserved, and a pressure level significantly above the control value was reached from the 20th min
  • It is concluded that DE is potent in suppressing VEBs but exerts negative inotropic effects that may be of clinical importance
  • The optimal antiarrhythmic dose is probably lower than that used in the present study

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