We investigated the effects of lycopene on H2O2-induced damage in neuroblastoma cells, as well as the underlying mechanisms
2020
Key concepts
Scholarcy highlights
- Lycopene demonstrated antioxidative damage properties in protecting the neural system in vitro
- Lycopene is a pigment derived from tomatoes and other red fruits, and has potent antioxidant and antitumor effects
- We investigated the effects of lycopene on H2O2-induced damage in neuroblastoma cells, as well as the underlying mechanisms
- Exposure to H2O2 markedly decreased the viability of SH-SY5Y cells and increased LDH release, both of which were reversed by lycopene pretreatment
- Overexpression of CHOP markedly reversed the antiapoptotic effects of lycopene, indicating that it is essential for the latter's protective effects
- The present study provides a novel preventive strategy against neurodegenerative diseases
- Increased consumption of lycopene-based products and lycopene-rich fruits and vegetables may result in a lower risk for neurodegenerative diseases
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