Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress

We investigated the effects of lycopene on H2O2-induced damage in neuroblastoma cells, as well as the underlying mechanisms

Shanshan Ou; Yinchao Fang; Hai Tang; Tong Wu; Lizhi Chen; Mei Jiang; Lingqi Zhou; Jie Xu; Kaihua Guo

2020

Scholarcy highlights

  • Lycopene demonstrated antioxidative damage properties in protecting the neural system in vitro
  • Lycopene is a pigment derived from tomatoes and other red fruits, and has potent antioxidant and antitumor effects
  • We investigated the effects of lycopene on H2O2-induced damage in neuroblastoma cells, as well as the underlying mechanisms
  • Exposure to H2O2 markedly decreased the viability of SH-SY5Y cells and increased LDH release, both of which were reversed by lycopene pretreatment
  • Overexpression of CHOP markedly reversed the antiapoptotic effects of lycopene, indicating that it is essential for the latter's protective effects
  • The present study provides a novel preventive strategy against neurodegenerative diseases
  • Increased consumption of lycopene-based products and lycopene-rich fruits and vegetables may result in a lower risk for neurodegenerative diseases

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