Global Analysis of DELLA Direct Targets in Early Gibberellin Signaling inArabidopsis

Our study reveals that DELLA proteins play two important roles in GA signaling: they help establish GA homeostasis by direct feedback regulation on the expression of GA biosynthetic and GA receptor genes, and they promote the expression of downstream negative components that are putative transcription factors/regulators or ubiquitin E2/E3 enzymes

Rodolfo Zentella; Zhong-Lin Zhang; Mehea Park; Stephen G. Thomas; Akira Endo; Kohji Murase; Christine M. Fleet; Yusuke Jikumaru; Eiji Nambara; Yuji Kamiya; Tai-ping Sun

2007

Scholarcy highlights

  • Bioactive gibberellins control a wide range of processes during plant development, including seed germination, leaf expansion, stem and root elongation, flowering time, and flower and fruit development
  • The DELLA proteins are conserved repressors of GA signaling that act immediately downstream of the GA receptor to modulate all aspects of GA-induced growth and development in plants
  • Our results indicate that DELLA proteins participate in two aspects of the GA signaling network: they help establish GA homeostasis by feedback regulating the expression of GA biosynthetic genes and GA receptors, and they promote the expression of downstream regulatory proteins that are putative negative components in GA signaling
  • To uncover early GAresponsive genes and those controlled by DELLA, we carried out two sets of microarray experiments
  • DELLA proteins are repressors that act directly downstream of the GA receptor to modulate all aspects of GA-induced growth and development in plants
  • We identified early GA- and DELLA-responsive genes that are putative DELLA direct targets in shoots of young Arabidopsis seedlings
  • Several putative DELLA target genes are predicted to function in transcriptional regulation or in proteolysis of downstream GA response components

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