Epicardium in Heart Development

We review current knowledge in cross-species epicardial involvement, in relation to lineage specification and differentiation during cardiac development

Yingxi Cao; Sierra Duca; Jingli Cao

2019

Scholarcy highlights

  • The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair
  • The heterogenous cell population that composes the epicardium originates primarily from a transient embryonic cell cluster known as the proepicardial organ
  • Characterized by its high cellular plasticity, the epicardium contributes to both heart development and regeneration in two critical ways: as a source of progenitor cells and as a critical signaling hub
  • There are many unanswered questions in the field of epicardial biology, the resolution of which will advance the understanding of cardiac development and repair
  • We review current knowledge in cross-species epicardial involvement, in relation to lineage specification and differentiation during cardiac development

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