Immunological Relationships Between Homologous Structural Polypeptides of Measles and Canine Distemper Virus

The major structural polypeptides of measles and canine distemper virus were isolated by SDS-polyacrylamide slab gel electrophoresis

C. Orvell; E. Norrby

2008

Scholarcy highlights

  • The major structural polypeptides of measles and canine distemper virus were isolated by SDS-polyacrylamide slab gel electrophoresis
  • A reciprocal immunological cross-reactivity between the NP polypeptides was demonstrated by the use of sera directed against native antigens
  • A close reciprocal immunological relationship between the F polypeptides was demonstrated by immune precipitation of labelled polypeptides
  • Immunological cross-reactivity between the HA polypeptides of the two viruses could not be demonstrated by use of the same technique neither with sera directed against denatured antigen nor with sera against native antigen when extracellular denatured 35S-methionine-labelled purified virions were used in immune precipitation
  • It is concluded that all the major structural polypeptides of measles and CDV show varying degrees of reciprocal immunological cross-reactions
  • Proceedings of the National Academy of Sciences of the United States of America 76:6601–6605

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