Abdominal adiposity and hot flashes among midlife women

We considered total abdominal adiposity and its components: subcutaneous adiposity and visceral adiposity

Rebecca C. Thurston; MaryFran R. Sowers; Kim Sutton-Tyrrell; Susan A. Everson-Rose; Tené T. Lewis; Daniel Edmundowicz; Karen A. Matthews


Scholarcy highlights

  • Every 1-SD increase in total and subcutaneous abdominal adiposity was associated with increased odds of hot flashes in age- and site-adjusted models
  • Consistent with the full Study of Women's Health Across the Nation cohort, factors significantly associated with reporting hot flashes were age, race/ethnicity, education, menopausal status, anxiety symptoms, FSH, E2, and free estradiol index
  • Greater total abdominal adiposity was significantly associated with higher odds of reporting hot flashes
  • The present findings demonstrated that women with increased abdominal adiposity, and subcutaneous abdominal adiposity, were more likely to report hot flashes
  • FSH and FEI were associated with both adiposity and hot flashes, adjusting for these hormones failed to attenuate the association between abdominal adiposity and hot flashes
  • Considering evidence of the thin hypothesis, FSH was significantly and positively associated with hot flashes, and E2 and FEI were significantly and negatively associated with hot flashes in fully adjusted models
  • This study evaluated how subtypes of adiposity, such as visceral versus subcutaneous abdominal adiposity, may show differential associations with hot flashes

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