Cognitive and Psychomotor Effects of Paroxetine and Sertraline on Healthy Elderly Volunteers

The authors evaluated the cognitive and psychomotor effects of serotonin reuptake inhibitors in healthy elderly volunteers

Patricia M. Furlan; Michael J. Kallan; Thomas Ten Have; Bruce G. Pollock; Ira Katz; Irwin Lucki

2009

Scholarcy highlights

  • The authors evaluated the cognitive and psychomotor effects of serotonin reuptake inhibitors in healthy elderly volunteers
  • Paroxetine, sertraline, and placebo were compared for 3 weeks of testing in a double-blind study with behavioral testing at baseline and at the end of each week
  • MANOVA models demonstrated no between-group differences; mixed-model random regression analyses revealed that Day 14 plasma paroxetine levels correlated negatively with delayed verbal recall and paired-associate learning scores
  • Plasma paroxetine levels were associated with mild behavioral impairment at Day 14, with no other significant adverse effects
  • Plasma sertraline levels were associated with mild and transient behavioral changes, as well as early termination in several subjects

Need more features? Save interactive summary cards to your Scholarcy Library.