Thyroid Disruptors: Extrathyroidal Sites of Chemical Action and Neurodevelopmental Outcome—An Examination Using Triclosan and Perfluorohexane Sulfonate

This study examined whether thyroid disrupting chemicals acting distinct from synthesis inhibition would result in the same alterations in brain as expected with PTU

Mary E Gilbert; Katherine L O’Shaughnessy; Susan E Thomas; Cal Riutta; Carmen R Wood; Alicia Smith; Wendy O Oshiro; Richard L Ford; Michelle Gatien Hotchkiss; Iman Hassan; Jermaine L Ford

2021

Scholarcy highlights

  • To whom correspondence should be addressed at Office of Research and Development, Center for Public Health and Environmental Assessment, Public Health Integrated Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27709, USA
  • This study examined whether thyroid disrupting chemicals acting distinct from synthesis inhibition would result in the same alterations in brain as expected with PTU
  • They further suggest that reliance on serum hormones as prescriptive of specific neurodevelopmental outcomes may be too simplistic and to understand thyroid-mediated neurotoxicity we must expand our thinking beyond that which follows thyroid hormone synthesis inhibition
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