MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

In order to consider those constraints when estimating f, we have extended the RelTime implementation such that the estimate of f produces estimates of AT that satisfy the calibration constraints

Koichiro Tamura; Glen Stecher; Daniel Peterson; Alan Filipski; Sudhir Kumar

2013

Scholarcy highlights

  • The Molecular Evolutionary Genetics Analysis software is developed for comparative analyses of DNA and protein sequences that are aimed at inferring the molecular evolutionary patterns of genes, genomes, and species over time
  • MEGA is currently distributed in two editions: a graphical user interface edition with visual tools for exploration of data and analysis results and a command line edition, which is optimized for iterative and integrated pipeline analyses
  • In version 6.0, we have added facilities for building molecular evolutionary trees scaled to time, which are clearly needed by scientists as an increasing number of studies are reporting divergence times for species, strains, and duplicated genes
  • In order to consider those constraints when estimating f, we have extended the RelTime implementation such that the estimate of f produces estimates of AT that satisfy the calibration constraints
  • If no calibration constraints are provided, only relative times and related statistical measurements will be produced by MEGA6, but users still have an option to specify them in the Tree Explorer where the timetree containing relative times is displayed
  • An outcome of this effort is a 64-bit command-line version of MEGA6 that supports the timetree analysis, which can be downloaded from www.mega software.net/reltime and used for very large sequence data sets

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