Pleural Plaques and the Risk of Pleural Mesothelioma

This review revealed that 13 of 17 mesothelioma case subjects had pleural plaques on histological slides, which indicates a close histological relationship between these two diseases

Jean-Claude Pairon

2013

Scholarcy highlights

  • Retired or unemployed workers previously occupationally exposed to asbestos were invited to participate in a screening program for asbestos-related diseases, including computed tomography scan, organized between October 2003 and December 2005 in four regions in France
  • Survival regression based on the Cox model was used to estimate the risk of pleural mesothelioma associated with pleural plaques, with age as the main time variable and time-varying exposure variables, namely duration of exposure, time since first exposure, and cumulative exposure index to asbestos
  • A statistically significant association was observed between mesothelioma and pleural plaques = 8.9, 95% confidence interval = 3.0 to 26.5; adjusted hazard ratios
  • 13 859 eligible subjects agreed to participate in the screening program, 7275 underwent CT scan, and 5825 of these CT scans were sent to our team centers
  • After exclusion of subjects with missing data for asbestos exposure parameters, subjects considered to be unexposed to asbestos by industrial hygienists, subjects with unreadable CT scan, and one subject considered to have a probable pleural tumor at the time of CT scan, the study population consisted of 5287 male subjects
  • In view of the frequency and prognosis of pleural mesothelioma at the present time, we believe that large-scale specific screening for pleural mesothelioma cannot be recommended in subjects previously exposed to asbestos with pleural plaques

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