Lung Cancer and Occupation in a Population-based Case-Control Study

To adjust for smoking, we evaluated different models and chose the one with the lowest Akaike Information Criterion

D. Consonni


Scholarcy highlights

  • Dario Consonni*, Sara De Matteis, Jay H
  • Population-based case-control study performed in 2002–2005 in Lombardy, northern Italy—the most populated, economically relevant, and industrialized region in Italy—we found a relative risk excess of 74% for men ever employed in occupations known to be associated with lung cancer, with the largest contributions from the ceramic and refractory brick and the nonferrous basic industries
  • Of the occupations suspected to be associated with lung cancer, we found a marked excess for filling station attendants and suggestive increases for bus and truck drivers and launderers and dry cleaners
  • Applying the population attributable fraction of 4.9% to the 4,515 incident male cases of lung cancer that occurred in 2005 in Lombardy, we estimated that 221 cases per year, or 181 for the education-adjusted PAF, were attributable to past employment in lists of occupations known occupations
  • These figures contrast with the low number of occupational lung cancers officially reported to and compensated by the National Insurance Institute for Work Injuries; for instance, in 1999– 2004, only 399 work-related lung cancer cases were reported in Lombardy, and about half of them were compensated
  • The low PAF for list A occupations among women was expected, given that exposure to most occupational lung carcinogens occurred in workplaces in which women constituted a minority
  • The 23% increased risk for bus and truck drivers deserves mention because it was based on a substantial number of exposed workers and because we found an excess for other motor vehicle drivers not included among list B occupations

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