In Vitro Profiling of the Endocrine-Disrupting Potency of Brominated Flame Retardants

The current study demonstrated such potencies for another eight polybrominated diphenyl ethers congeners, of which BDE-100 and BDE-49 are the most environmentally relevant

Timo Hamers; Jorke H. Kamstra; Edwin Sonneveld; Albertinka J. Murk; Monique H. A. Kester; Patrik L. Andersson; Juliette Legler; Abraham Brouwer

2006

Scholarcy highlights

  • Over the past 50 years, petroleum-based polymeric materials have increasingly been used in construction materials, textiles, and computer equipment
  • Given the structural similarity between polybrominated diphenyl ethers and polychlorinated biphenyls, PBDEs follow the PCB nomenclature proposed by Ballschmitter and Zell
  • ARantagonistic responses were among the highest of all bioassay responses determined in the present study, with maximum potencies for brominated diphenyl ether-19 and BDE-100 being higher than for flutamide, an antiandrogenic drug used in prostate cancer treatment
  • Antiandrogenic, antiprogestagenic,estrogenic,dioxin-like, and T3-antagonistic potencies of brominated flame retardants were demonstrated at the receptor level
  • For some BFRs, the ED potency was higher than for natural ligands or clinical drugs used as positive controls, viz, androgen receptor antagonism by di-ortho--substituted PBDEs with no bromine substitutions adjacent to each other, and T4-TTR competition and E2SULT inhibition by hydroxylated BFRs
  • Based on similarity in ED profiles, BFRs could be classified into five different clusters
  • These findings support further investigation of the potential ED effects of these brominated flame retardants in man and wildlife

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