Toxicity and Tissue Distribution of Magnetic Nanoparticles in Mice

Our results demonstrated that magnetic nanoparticles of 50-nm size did not cause apparent toxicity under the experimental conditions of this study

Jun Sung Kim

2005

Scholarcy highlights

  • The recent shift in the focus of developing nanoparticles from microscale to nanoscale is essential for future advances in both the digital revolution and modern biology and may change the very foundations of education, medicine, and industrial manufacture and have a potential harmful effect on the environment
  • Treatment with magnetic nanoparticles@SiO2(RITC) for 4 weeks did not cause any adverse effects on growth because no statistically significant differences in the body weight gain were observed between the MNP-treated mice and control mice
  • MNPs@SiO2(RITC) could penetrate the blood–brain barrier and gain access to the brain in a time-dependent manner, because the intensity of the fluorescence increased with time
  • Merging the images of neuronal nuclei-FITC and MNP-rhodamine B isothiocyanate clearly demonstrated that the presence of the MNPs in the brain was due to true uptake of the MNPs by a brain neuron
  • The main reason for developing nanotechnology is to extend the limits of sustainable development at the nanoscale with less consumption of energy, water, and materials, and waste minimization
  • Current approaches strongly suggest that consequences of nanotechnology are best addressed within the existing system applications such as biology, chemistry, or electronics
  • We report here that magnetic nanoparticles@SiO2(RITC) can penetrate the blood–brain barrier and persist in the body for a long time without causing toxicity

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