Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)

This study shows that the rapid appearance of drug-resistant virus in serum is followed by an increase in viral RNA load

R. Schuurman; M. Nijhuis; R. van Leeuwen; P. Schipper; D. de Jong; P. Collis; S. A. Danner; J. Mulder; C. Loveday; C. Christopherson; S. Kwok; J. Sninsky; C. A. B. Boucher

2011

Scholarcy highlights

  • The effect of the appearance of drug-resistant human immunodeficiency virus type 1 on viral RNA load was studied in patients treated with the reverse transcriptase inhibitor lamivudine
  • A marked decline in the amount of HIV-I RNA and HIV-I p24 antigen was observed within 2 weeks, followed by a rise that coincided with the appearance of lamivudine-resistant viruses in serum
  • After 12 weeks, a partial antiviral effect was observed despite the presence of a complete codon 184 mutant virus population in serum
  • This study shows that the rapid appearance of drug-resistant virus in serum is followed by an increase in viral RNA load

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