Mathematical study of in-host dynamics of Chlamydia trachomatis

Based on the parameter values used in the numerical simulations, this study shows that a future Chlamydia vaccine that boosts cell-mediated immune response would be quite effective in reducing Chlamydia burden

O. Sharomi; A. B. Gumel

2010

Scholarcy highlights

  • The paper presents a deterministic model for the dynamics of Chlamydia trachomatis inside the body of an infected human host
  • The extended model has a globally asymptotically stable Chlamydia-free equilibrium whenever its associated reproduction threshold is less than unity, and the disease persists when the threshold exceeds unity
  • Numerical simulations of the extended model show that cell-mediated immune response is more effective than humoral immune response
  • Based on the parameter values used in the numerical simulations, this study shows that a future Chlamydia vaccine that boosts cell-mediated immune response would be quite effective in reducing Chlamydia burden

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