THE CEREBRAL METABOLISM OF GLUCOSE AND OXYGEN MEASURED WITH POSITRON TOMOGRAPHY IN PATIENTS WITH MITOCHONDRIAL DISEASES

These findings indicate that in patients with a mitochondrial encephalopathy the defect identified in skeletal muscle is expressed in the brain

R. S. J. FRACKOWIAK

2007

Scholarcy highlights

  • Cerebral oxygen and glucose metabolism have been studied in 8 patients with biochemically defined mitochondrial myopathies and 7 normal control subjects using positron emission tomography
  • Patients with major central nervous system disease showed an uncoupling of glucose and oxygen metabolism when compared with patients without cerebral disease and normal subjects
  • Patients with major CNS disease showed a 50% reduction in cerebral oxygen utilization compared with cerebrally unaffected patients and normal subjects
  • These findings indicate that in patients with a mitochondrial encephalopathy the defect identified in skeletal muscle is expressed in the brain

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