SUBSTANCE P AND THE SENSORY INNERVATION OF INTRACRANIAL AND EXTRACRANIAL FELINE CEPHALIC ARTERIES

Substance P, a putative neurotransmitter peptide present in a subpopulation of small sensory neurons, was measured in the walls of feline cranial arteries and systemic veins and arteries using a sensitive and specific radioimmunoassay

THORKILD V. NORREGAARD

2007

Scholarcy highlights

  • Substance P, a putative neurotransmitter peptide present in a subpopulation of small sensory neurons, was measured in the walls of feline cranial arteries and systemic veins and arteries using a sensitive and specific radioimmunoassay
  • Extracranial arteries were decreased on average by 78 per cent, whereas intracranial arteries were reduced by 55 per cent
  • Unilateral removal of the superior cervical sympathetic ganglion was without effect
  • The described pattern of sensory innervation provides a possible explanation for the referral of pain to the forehead and anterior scalp during attacks of migraine, and with arteritis and thrombosis involving vascular structures within the posterior fossa, the circle of Willis and the external carotid system of man

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