CYP17 Gene Polymorphisms: Prevalence and Associations with Hormone Levels and Related Factors. A HuGE Review

We review and synthesize the findings of studies on the prevalence and effects of polymorphisms in the cytochrome P-450c17α gene

L. Sharp

2004

Scholarcy highlights

  • GENE The cytochrome P-450c17α gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P450c17α, which functions at key branch points in steroid hormone biosynthesis in the adrenal gland, ovary, and gonads
  • We review and synthesize the findings of studies on the prevalence and effects of polymorphisms in the CYP17 gene
  • We reviewed studies of the association between CYP17 genotype and circulating hormone levels, markers of hormonal status, or phenotypes associated with an abnormal hormonal milieu
  • African-American, and Asian volunteers aged 18–33 years, recruited through advertisements, who had never had a pregnancy of ≥12 weeks, were not obese, and had not taken OCs or hormonal medications in the past 3 months, with a currently ovulatory menstrual cycle estimated to be of 25–32 days
  • Postmenopausal women recruited into the Nurses’ Health Study in 1976 with a blood sample collected in 1989–1990 who were cancer free in 1996 and had not used hormone replacement therapy within 3 months of blood drawing
  • SHBG*, luteinizing higher‡; bioavailable hormone, and AAG* testosterone: 2% lower
  • Data on Hispanic populations are limited to two small US series in which the frequency was intermediate between that for Whites and that for East Asian populations

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