Anorexia of aging: physiologic and pathologic

These findings suggest that older persons have a global defect in their regulation of energy intake that puts them at risk for developing either positive or negative energy balance

J E Morley

2018

Scholarcy highlights

  • L activity and altered metabolism with aging
  • I examine the mechanisms responsible for the physiologic anorexia of aging that occurs in response to decreases in metabolism and physical activity with age
  • Opioid receptor appears to be the major regulator at least in rodents, drinking appears to be predominantly under control of the j. opioid receptor. When these findings are coupled with the fact that the major decrease in food intake in older persons is related to decreased fat ingestion, there appears to be some presumptive evidence that a decline in the opioid feeding drive may play a role in development of the physiologic anorexia of aging
  • Testosterone, and in particular free or bioavailable testosterone, concentrations have been shown to decline with aging in both cross-sectional and longitudinal studies. This decline in testosterone concentrations may play a role in the decreased food intake with aging, and testosterone replacement studies have suggested a role for testosterone in the development of age-related sarcopenia and increased body fat
  • (67), and testosterone concentrations decline longitudinally with aging. These findings suggest a possible role for leptin in the circuitry involved in producing the physiologic anorexia of aging in males
  • Having reviewed the factors involved in the physiologic anorexia of aging, the remainder of this review focuses on the group of older persons who tend to have malnutrition
  • Depression is the most common treatable cause of anorexia in older persons

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