In vitro Potential Effect of Morin in the Combination with β-Lactam Antibiotics Against Methicillin-Resistant Staphylococcus aureus

We explored the combined effect of morin with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus, a multidrug-resistant pathogen

Su-Hyun Mun

2015

Scholarcy highlights

  • Morin, a plant-derived flavonol, is known to be an effective inhibitor of Gram-positive bacteria
  • We explored the combined effect of morin with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus, a multidrug-resistant pathogen
  • The anti-MRSA activity of morin was investigated by the broth microdilution method, checkerboard dilution test, and time-kill curve assay
  • An increased susceptibility of MRSA toward oxacillin was observed in the presence of morin
  • The present study indicates that the killing effect by the combinative treatment of morin and β-lactam antibiotic is dependent on the PBP2a-mediated resistance mechanism

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