Dissecting Redox Biology Using Fluorescent Protein Sensors

We review the growing range of thiol redox sensor variants and their application in different cells, tissues, and organisms

Markus Schwarzländer; Tobias P. Dick; Andreas J. Meyer; Bruce Morgan

2015

Scholarcy highlights

  • Fluorescent protein sensors have revitalized the field of redox biology by revolutionizing the study of redox processes in living cells and organisms
  • Critical Issues: widely used as an established standard tool, important questions remain surrounding their meaningful use in vivo
  • We review the growing range of thiol redox sensor variants and their application in different cells, tissues, and organisms
  • We highlight five key findings where in vivo sensing has been instrumental in changing our understanding of redox biology, critically assess the interpretation of in vivo redox data, and discuss technical and biological limitations of current redox sensors and sensing approaches
  • Future Directions: We explore how novel sensor variants may further add to the current momentum toward a novel mechanistic and integrated understanding of redox biology in vivo

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