Thyroid Hormone Receptor Coactivators and Corepressors

In the absence of triiodothyronine, thyroid hormone receptors repress transcription of many genes; in the presence of T3, TRs activate transcription of those same genes. Both of these events are dependent on interactions between TRs and other nuclear proteins

RONALD J. KOENIG

2009

Scholarcy highlights

  • In the absence of triiodothyronine, thyroid hormone receptors repress transcription of many genes; in the presence of T3, TRs activate transcription of those same genes. Both of these events are dependent on interactions between TRs and other nuclear proteins
  • TRs bind to specific DNA sequences, generally found in the 5′ flanking regions of target genes
  • The binding of T3 causes a conformational change in the TR that results in release of the corepressor and recruitment of coactivator proteins
  • Gene activation by T3 is a two-step process; removal of active repression, and induction of transcription to levels above the "neutral" state

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