Nrf2 Defends the Lung from Oxidative Stress

Nuclear factor, erythroid 2 related factor 2 belongs to the Cap'n'collar/basic region leucine zipper transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents

Hye-Youn Cho; Sekhar P. Reddy; Steven R. Kleeberger

2006

Scholarcy highlights

  • Nuclear factor, erythroid 2 related factor 2 belongs to the Cap'n'collar/basic region leucine zipper transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents
  • Deficiency of nrf augmented injury caused by bleomycin and environmental oxidants including hyperoxia, diesel exhaust particles, and cigarette smoke
  • Microarray analyses of lungs from nrf2-deficient and -sufficient mice identified Nrf2-dependent genes that might be critical in pulmonary protection
  • Observations from these studies highlight the importance of the Nrf2-antioxidant pathway and may provide new therapeutic strategies for acute respiratory distress syndrome, idiopathic pulmonary fibrosis, cancer, and emphysema in which oxidative stress is implicated

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