Surface modification of graphene nanopores for protein translocation

We report a study of protein translocation through chemically modified graphene nanopores

Y P Shan; P B Tiwari; P Krishnakumar; I Vlassiouk; W Z Li; X W Wang; Y Darici; S M Lindsay; H D Wang; S Smirnov; J He

2013

Scholarcy highlights

  • Nanopore based analysis is an emerging technique, showing promises in DNA sequencing, genetics, protein analysis and medical diagnostics
  • Since there are no ionizable groups in DPPEPEG750 for this range of pH and a similar pH dependence was observed for modifications by C16, we believe that the effect is likely due to the surface groups on graphene generated by the oxygen plasma treatment
  • Translocation of gold nanoparticles through such treated nanopores was observed as spikes in ionic conductance
  • This modification was insufficient in preventing protein adsorption onto the graphene surface and for the protein translocation events, additional treatment was required
  • The effect is sensitive to the protein size and shape as no translocation events were detected for another protein, bovine serum albumin
  • It may include attachment of receptor molecules at the edge of the graphene nanopores to enhance the discrimination of proteins in the ionic readout signal

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