Ultrasensitive label-free DNA analysis using an electronic chip based on carbon nanotube nanoelectrode arrays

We report the detection of DNA PCR amplicons using an ultrasensitive label-free electronic technique based on multiwalled carbon nanotube nanoelectrode arrays embedded in an SiO2 matrix

Jessica Koehne; Hua Chen; Jun Li; Alan M Cassell; Qi Ye; Hou Tee Ng; Jie Han; M Meyyappan

2004

Scholarcy highlights

  • We report the detection of DNA PCR amplicons using an ultrasensitive label-free electronic technique based on multiwalled carbon nanotube nanoelectrode arrays embedded in an SiO2 matrix
  • The inherent guanine bases in the DNA amplicon target of bases serve as signal moieties with the aid of Ru(bpy)32+ mediators, providing an amplified anodic current associated with the oxidation of guanine groups at the nanoelectrode surface
  • The reduced size and density of the nanoelectrode array provided by MWNTs dramatically improves the sensitivity of EC detection
  • This platform can be employed for developing highly automated electronic chips with multiplex nanoelectrode arrays for quick DNA analysis

Need more features? Save interactive summary cards to your Scholarcy Library.