Use of Streptogramin Growth Promoters in Poultry and Isolation of Streptogramin‐ResistantEnterococcus faeciumfrom Humans

We found higher point estimates for both raw poultry contact and poultry consumption in persons without recent antibiotic use, but not all of these were statistically significan

Amy L. Kieke; Mark A. Borchardt; Burney A. Kieke; Susan K. Spencer; Mary F. Vandermause; Kirk E. Smith; Selina L. Jawahir; Edward A. Belongia; Marshfield Enterococcal Study Group

2006

Scholarcy highlights

  • Virginiamycin use in poultry selects for Enterococcus faecium with cross-resistance to quinupristindalfopristin, a drug for vancomycin-resistant E. faecium in humans
  • Poultry exposure is associated with a quinupristin-dalfopristin resistance gene and inducible quinupristin-dalfopristin resistance in human fecal E. faecium
  • The continued use of virginiamycin may increase the potential for streptogramin-resistant E. faecium infection in humans
  • E. faecium was isolated from 105 hospital patients and 65 vegetarians; further analyses were restricted to this group
  • A previous study in the United States found that fecal E. faecium with constitutive quinupristin-dalfopristin resistance are rare in humans, but that study did not evaluate the prevalence of streptogramin resistance genes or inducible resistance
  • The hospital patients without recent antibiotic use had a increased risk of carrying E. faecium isolates with vatE if they had touched raw poultry
  • The results of the present study suggest that the FDA model may underestimate the true risk of foodborne acquisition, because streptogramin resistance genes are commonly found in human fecal E. faecium, despite the absence of constitutive streptogramin resistance
  • Presented in part: 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, 16–19 December 2005

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