Tau protein binds to microtubules through a flexible array of distributed weak sites.

Tau protein plays a role in the extension and maintenance of neuronal processes through a direct association with microtubules

K A Butner; M W Kirschner

2004

Scholarcy highlights

  • Tau protein plays a role in the extension and maintenance of neuronal processes through a direct association with microtubules
  • To characterize the nature of this association, we have synthesized a collection of tau protein fragments and studied their binding properties
  • The binding energy for microtubules is delocalized and derives from a series of weak interactions contributed by small groups of amino acids
  • The flexible structure of the tau protein binding interaction may allow it to be displaced from the microtubule lattice and may have important consequences for its function

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